Name: Project Reset
Address: SG

What is Project RESET?

Project RESET is a 5-year government-funded research initiative. It aims to gain a deeper understanding about Singapore population's metabolism, heart and liver health as well as lifestyle behaviour to prevent heart diseases, including heart attack and stroke.

About Project RESET

You will receive

A smartwatch

Track your physical activity and sleep

Free Scans & Blood Test

Up to 5 visits per year, results returned upon request

Reimbursement

For your time and effort

What Your Journey Will Look Like!

Participant Visit Schedule v3_Dec 2025_p

Redirecting Poor Sleep Drivers of Early Cardiovascular Disease (RESET-Oura Study) (NUS-IRB-2024-727)

Led by Professor Michael Chee and colleagues from the Centre for Sleep & Cognition at NUS, this study seeks to understand how sleep and wellbeing patterns relate to markers of cardiovascular health collected in the parent RESET study. Participants, who must already be enrolled in RESET, wear an Oura ring — a finger-worn wearable that tracks movement, heart rate, and temperature — continuously over a 2-year period to monitor their sleep and physical activity. They also complete daily mood and wellbeing surveys via a smartphone app. The data collected is then linked to cardiovascular health outcomes from the RESET study to identify how poor sleep may contribute to early cardiovascular disease. Up to 1,500 participants are expected to be recruited, and those who comply with at least 80% data collection over the 2 years get to keep their Oura ring.

RESET SUB STUDIES

Project RESET-VISION: Retinal Imaging for Systemic and Cardiovascular Health (NUS-IRB-2026-25)

Led by Dr Tham Yih Chung from the Department of Ophthalmology at NUS, this study is a sub-study of the larger Project RESET cohort. It aims to evaluate whether retinal imaging and visual acuity measurements can serve as biomarkers for cardiometabolic and vascular disease. The premise is that the small blood vessels visible in the retina may provide clues about a person's heart and metabolic health. Participants — Singaporean citizens or PRs aged 40–70 with an elevated cardiovascular risk score — undergo a roughly 30-minute session involving a medical history questionnaire, a visual acuity test, and non-invasive retinal imaging (fundus photography and OCT scans) of both eyes. The study aims to recruit approximately 3,000 participants and is conducted at NUS MD6.

JOIN US

Redirecting Poor Sleep Drivers of Early Cardiovascular Disease (RESET-Oura Study) (NUS-IRB-2024-727)

Improving LDL-C Levels Through Personality-Tailored Health Messages (NUS-IRB-2025-334)

Led by Assistant Professor Jocelyn Chew from the Alice Lee Centre for Nursing Studies at NUS, this three-arm randomised controlled trial investigates whether personality-tailored health messages can be more effective than generic messages in encouraging RESET participants with high LDL-C (bad cholesterol) levels to seek medical consultation and commit to lifestyle changes. Participants are randomly assigned to one of three groups: one receiving a personality-tailored health message embedded in their RESET results, one receiving a general health message, and one receiving no message at all. They complete questionnaires at baseline and again 3 months after receiving their RESET results, covering topics such as sociodemographic data, personality traits (using the Big Five Inventory), and their intentions to make lifestyle modifications. The study is conducted entirely online and aims to recruit approximately 3,000 participants.

JOIN US

Insulin Sensitivity & Intervention with Real-time Evaluation using CGM (RESET-INSPIRE) (NUS-IRB-2025-740)

Led by Professor Roger Foo and Assistant Professor Jocelyn Chew from the Centre for Translational Medicine at NUS, this study primarily aims to develop an algorithm that can assess insulin sensitivity through the use of a Continuous Glucose Monitor (CGM). It also evaluates whether combining CGM with lifestyle education can improve a range of metabolic health markers such as BMI, waist circumference, and insulin sensitivity. The study recruits adults aged 21 to 70 and expects to enrol 270 participants. It is conducted in two phases over a maximum of 20 weeks: in Phase 1, all participants undergo an Oral Glucose Tolerance Test (OGTT) and wear a CGM for 15 days; in Phase 2, those identified as having impaired insulin sensitivity are randomly assigned to either receive a CGM with lifestyle education or neither. Blood samples are also collected at key timepoints for multi-omics and biobanking research.

JOIN US

Public Attitudes Towards Bioprediction of Cardiovascular Diseases Using AI and Big Data Analytics (NUS-IRB-2024-913)

Led by Dr Serene Ong and Professor Julian Savulescu from the Centre for Biomedical Ethics (CBmE) at NUS, this study aims to analyse public attitudes towards the use of AI and big data analytics in predicting cardiovascular disease (CVD), as well as towards nudging and persuasive technologies designed to encourage healthier lifestyles. Specifically, it examines respondents' views on bioprediction of CVD, data privacy, the use of AI and big data in health analytics, and perceptions of moral responsibility regarding personal health. The study targets 1,000 participants who had previously consented to future research under Project RESET, and is conducted as a fully anonymous, one-time online survey via NUS Qualtrics, taking less than 15 minutes to complete. The overarching goal is to build public trust and social acceptance — referred to as a "social licence to operate" — for AI-driven health prediction systems.

Everyday Health and Wellbeing (HWB) Practices amongst Older Adults (NUS-IRB-2024-1123)

Led by Wong Kai Wen and Professor Elaine Ho from the NUS Department of Geography, this study aims to understand how older adults (aged 55–70) in Singapore manage their health and wellbeing in their day-to-day lives. It explores a broad range of practices — from physical exercise and stress management to social activities — and seeks to identify the biological, social, and environmental factors that shape these behaviours. Participants take part in three sessions over 1–2 months: an opening interview about their daily routines and life experiences, a 7-day biosensing period using a Garmin smartwatch (issued by Project RESET) to track metrics like steps, sleep, and stress levels, and finally a go-along interview where the researcher accompanies participants during their everyday activities. With around 50 participants involved, the findings are intended to inform future research and policy related to older adult wellbeing in Singapore.

A Health-Coach Led Digital Lifestyle Intervention (HEALDI) for the Regression of Diffuse Myocardial Fibrosis (NHG DSRB: 2024-3874)

Led by Professor Wang Wenru from the Alice Lee Centre for Nursing Studies at NUS Yong Loo Lin School of Medicine, this randomised controlled trial aims to evaluate the effectiveness of a health coach-led digital lifestyle intervention (HEALDI) for patients with hypertensive heart disease. The intervention combines AI technology, a mobile application, and guidance from a trained health coach to assess its impact on heart, liver, brain and metabolic health, the adoption of healthy behaviours such as physical activity, sleep quality, dietary practices and medication adherence, as well as overall quality of life. A total of 200 participants aged 40–70 are recruited from the Project RESET cohort and randomly assigned to either the HEALDI intervention group — which involves wearing a smartwatch, using a mobile app, and attending remote health coaching sessions over 12 months — or a control group that only wears the smartwatch. All participants are followed up over a 3-year period with assessments at 6, 12, 24, and 36 months, involving a range of procedures including MRI scans, blood tests, and questionnaires.

What is Project RESET?

You will receive

A smartwatch

Track your physical activity and sleep

Free Scans & Blood Test

Up to 5 visits per year, results returned upon request

Reimbursement

For your time and effort

What Your Journey Will Look Like!

RESET SUB STUDIES

Participate in Project RESET now!